BioCep has developed a revolutionary method for separation of immunomagnetic marked cells. BioCep’s abilities and those of its CEP platform are exceptional, as they are the result of many years of research and development. BioCep’s Cell Enrichment Process yields a comparably large number of viable cells with increased purity of the cell population in comparison to existing methods. The system's flexibility combined with its unique features allows BioCep to develop a wide range of medical applications based on cell separation. The CEP is poised to become the preferred method of cell separation in research laboratories, due to its superiority. BioCep will market the CEP to research laboratories worldwide, as well as consumable kits for cell separation.
Innovative Flow-Through Immunomagnetic Cell Separation
The CEP represents a novel design in biomagnetic isolation systems. The technology combines the best of continuous flow technology with a unique, “virtual mesh” design producing unrivaled separation of specimens, into desired and undesired cells. The CEP incorporates strong magnets, a metal frame, and silicon tubing. The magnets and frame form three active air gaps through which the magnetic flux lines pass, creating mesh-like harvesting areas that attract the immunomagnetic marked cells. As the specimen flows through a silicon tubing, the marked cells are held in stasis by the magnetic flux lines while the non-marked cells pass through and out of the system.
The significance of the magnetic, closed circuit, generated "virtual mesh", is the total elimination of any surface contact with the targeted cells. Also unique is the continuous, linear separation areas created by use of tubing as both the transport and separation vessels. The results are significantly higher yields of targeted cells with little or no change in their original morphological condition.
The system allows parameter definition, such as, the intensity of the magnetic field, system capacity, separation time and more. CEP uses easily assembled, disposable tubing for specimen transfer, which is changed for each new specimen undergoing separation.
This platform can be applied in many procedures, many of them currently without a suitable solution for cell separation, due to the limitations of existing technologies. Acceptance of BioCep’s platform as the preferred method of cell separation will increase the number of applications suitable for utilizing it.
CEP's Advantages
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Magnetic closed circuit – The CEP apparatus forces the flux lines to pass through the separation area, creating extraordinarily strong virtual magnetic fields. These strong fields can attract either very small or a very large number of marked cells, as required by the application.
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Improved separation of specific sub-populations - The CEP allows definition of the intensity of the magnetic field, allowing for instance, separation of cells that express a specific antigen at a certain density, or cells expressing two or more antigens, as opposed to only one, to name a few.
